Schematic Engineering Industries manufactures a comprehensive range of Granulation Isolators designed to support diverse pharmaceutical production processes, including wet and dry granulation. These isolators accommodate granulators, fluid bed dryers, dry and wet mills, and blenders, with options tailored for various scales:

• 200g – 2kg: Ideal for research and development labs
• 600g – 5kg
• 2kg – 10kg

Wet Granulation Line

Wet granulation involves adding a liquid solution, such as water, ethanol, or isopropanol, to a powder mixture to produce granules. Once the mixture forms a dense mass, the granulation fluid is evaporated, and the granules are milled to the desired size for compression. This method remains a preferred choice for substances where direct compression is unsuitable, even when processing water-sensitive drugs, thanks to advanced equipment like fluidised beds.

Schematic supplies equipment and barrier isolators for every stage of the wet granulation process, including feed stations, milling, sieving, high-shear mixing, fluid bed processing, and blending. Integrated solutions are also available for tablet press and coating machines, complete with vacuum powder transfer systems and CIP/WIP systems.

Applications include producing dense, uniform granules for solid dosage forms, such as anti-neoplastic agents and hormone-based drugs (OEB3). An example system includes a 2kg Granulation Line Barrier Isolator with a Rapid Mix Granulator (RMG), Fluid Bed Dryer (FBD), and Multi-Mill Blender Workstations.

Dry Granulation Line

Dry granulation forms granules without the use of liquid solutions, making it ideal for moisture-sensitive or heat-sensitive formulations. The process involves compacting and size reduction to create free-flowing, uniform granules.

There are two primary methods:

1. Slugging: Produces large tablets in a heavy-duty press.
2. Roller Compaction: Uses an auger-feed system to deliver powder between two pressure rollers, followed by milling and blending before tablet compression.

Schematic’s Dry Granulation Barrier Isolators are designed to optimise this process, featuring workstations for dry milling, weighing and dispensing, hoisting, hammer milling, and sieving. These isolators ensure safety and efficiency in handling hazardous or potent materials while maintaining precise granulation quality.

Schematic’s expertise in granulation processes ensures tailored solutions for every production need, delivering safety, compliance, and optimal performance.